Skip to Content (Press Enter) Skip to Footer (Press Enter)

Polyglutamic Acid FAQs

Polyglutamic acid is a naturally derived peptide that boasts hydration benefits that surpass even hyaluronic acid (HA). Found in fermented soybeans, it can hold up to 5,000 times its weight in water, making it one of the most effective hydrating agents on the market.

While hyaluronic acid penetrates deeper layers of the skin, polyglutamic acid works on the surface to create aplump + dewy finish.

This ingredient offers a host of skin-transforming benefits, including:


• Deep hydration: PGA locks in moisture on the skin's surface to keep it hydrated + plump for longer periods.
• Skin barrier support: Strengthens the skin's natural barrier to protect against environmental damage
and water loss.
• Anti-aging properties: Reduces the appearance of fine lines and wrinkles by keeping skin hydrated
+ firm.
• Enhanced skin texture: Helps smooth out rough patches to leave skin soft + silky. • Suitable for all skin types: Non-irritating and safe for sensitive skin, delivering hydration without any
harsh effects.

Polyglutamic acid is a versatile ingredient that works with all skin types. If you have dry skin, the intense hydrating properties of PGA help combat dryness by sealing in moisture. For oily skin, it works well because it's lightweight, non-greasy, and noncomedogenic (doesn't clog pores).

Sensitive skin benefits from its gentle + soothing nature, which helps to minimize irritation while strengthening the skin barrier. Mature skin can also enjoy its anti-aging benefits, such as plumping fine lines + boosting
hydration.

Adding PGA to your existing regimen is simple. Follow these steps to introduce it to your skincare staples:

  1. Cleanse: Start with a gentle cleanser to remove dirt and makeup, prepping your skin to absorb additional products.
  2. Apply a toner: Use a balancing toner to restore your skin's pH levels and add a layer of moisture.
  3. Use polyglutamic acid serum: Dispense a small amount of PGA serum and gently press onto slightly damp skin for optimal absorption. We recommend the ZO® Illuminating AOX Serum.
  4. Layer other treatments: Apply active ingredients like vitamin C, niacinamide, or retinol after your PGA serum.
  5. Seal with a moisturizer: Lock in the benefits by using your favorite hydrator.
  6. Finish with sunscreen (AM): Protect your skin from harmful UV rays by applying a broad-spectrum sunscreen during your morning routine.

Absolutely. Polyglutamic acid is an adaptable ingredient that pairs well with most skincare actives, enhancing their effectiveness while keeping your skin hydrated + balanced. Some compatible ingredients include:

  • Hyaluronic acid: Apply hyaluronic acid first to draw water into the skin, then follow with PGA to lock it in for long-lasting moisture.
  • Vitamin C: Pair PGA with vitamin C to amplify hydration + enhance your skin's glow. PGA reduces potential dryness sometimes associated with vitamin C products.
  • Niacinamide: This duo works wonders for improving skin texture + minimizing pores.
  • Retinol: Retinol can sometimes cause irritation but PGA can help counteract this by soothing the skin.

Both polyglutamic acid and hyaluronic acid are powerful hydrating ingredients but they differ in their structure and benefits, and in how they work on your skin.

PGA holds up to 5,000 times its weight in water compared to HA (1,000 times), making it more effective at retaining moisture. It also has a larger molecular structure, which allows it to sit on the surface of the skin and act as a barrier.

However, PGA and HA aren't competitors—they're complementary. Use hyaluronic acid first to hydrate deeper layers of the skin. Apply polyglutamic acid afterward to seal in hydration and enhance overall results.

Polyglutamic acid is a safe and gentle ingredient, with minimal risk of irritation or side effects. Rarely, some may experience mild redness or itching, usually due to sensitivities to other ingredients in the product.

Overuse can cause pilling, especially if not layered correctly. To minimize risks, patch-test before use, apply a thin layer, and allow products to absorb fully.

Avoid using immediately after harsh treatments or exfoliants to prevent irritation. If you need further advice on how to use PGA, consult your local ZO® Authorized Physician.

Shop our medical-grade collection of polyglutamic serums and moisturizers to achieve visibly smoother, plumper skin. For advice on any of our products or support with your existing regimen, get in touch with our expert team of ZO® Skincare Specialists today.

Back to top