Free Ground Shipping On Any Order*

Receive Up to 10% Off + Free Shipping On All Subscription Deliveries* Read More
Welcome to the ZO Skin Health Store for:
Find a Professional

Anti-Aging Skincare

ZO® anti-aging products are designed to address both the visible signs and key triggers of aging at every phase. Our specially formulated anti-aging skincare improves the texture and appearance of skin via clinically proven active ingredients

Anti-Aging
21 Results
Wrinkle + Texture 0.3 Wrinkle + Texture 0.3
New
Wrinkle + Texture 0.3
Formulated with 0.3% Retinol
$170.00
Retinol Skin Brightener 0.3 Retinol Skin Brightener 0.3
New
Retinol Skin Brightener 0.3
Formulated with 0.3% Retinol
$170.00
Clear Renewal Clear Renewal
New
Clear Renewal
Formulated with 0.3% Retinol
$170.00
Growth Factor Serum Growth Factor Serum
New
Growth Factor Serum

Growth Factor Serum is an advanced serum clinically shown to restore younger-looking skin. Powered by safely synthesized, human-comparable growth factors, this next-generation formula delivers targeted signaling to improve the appearance of skin density, elasticity, firmness, and smoothness. After 8 weeks of use, users reported thicker, smoother, more supple skin that appears nearly 6 years younger.*

 

Clinically Tested | Non-Comedogenic | Formulated without Gluten | Paraben Free

 

Named Best Growth Factor in The 2026 Shape Skin Awards: Editor-Tested & Dermatologist Approved Breakthrough -Shape

Named Best Growth Factor Serum in The Midlife Beauty O-wards -Oprah Daily

 

$200.00
4.3 (1712)
Anti-Aging

Skin does not age because it stops functioning.

Learn More
Peptide Facial Refining Concentrate Peptide Facial Refining Concentrate
New
Peptide Facial Refining Concentrate

Discover Peptide Facial Refining Concentrate, an advanced peptide face serum that complements the visible effects of neurotoxins and dermal fillers in a single step. This next-generation anti-wrinkle peptide concentrate is powered by four cutting-edge peptide technologies that work synergistically to smooth lines, improve elasticity + restore facial volume. In just 12 weeks, skin looks more lifted, structured + refined, with visibly improved facial geometry + youthful definition.


Alcohol and fragrance-free

$265.00
4.3 (35)
Neck Complex Anti-Aging + Brightening Serum Neck Complex Anti-Aging + Brightening Serum
New
Neck Complex Anti-Aging + Brightening Serum

Multi-faceted formula delivers visible renewal of the neck & décolleté. Clinically shown to firm + tighten the appearance of skin for a visibly more defined neck contour, while delivering a more even-looking skin tone.

Alcohol and fragrance- free

$155.00
4.8 (28)
Daily GSR + Skin Barrier Defense Program Daily GSR + Skin Barrier Defense Program
New
Daily GSR + Skin Barrier Defense Program

Kit of skincare essentials to help strengthen

+ maintain healthy-looking skin

$110.00
4.5 (491)
Anti Aging High Potency Retinol Program Anti Aging High Potency Retinol Program
New
Anti Aging High Potency Retinol Program

Designed to help reduce the appearance of

deeper lines + wrinkles

$295.00
4.2 (405)
Anti-Aging Program Kit Anti-Aging Program Kit
Out of Stock
Anti-Aging Program Kit

Designed to help reduce the appearance of

early signs of aging

$315.00
4.5 (613)
Growth Factor Eye Serum Growth Factor Eye Serum
Best Seller
Growth Factor Eye Serum

Improves the appearance of expression lines, creasing

+ hollowness and re-invigorates the look of tired eyes

$140.00
4.0 (474)
Radical Night Retinol Radical Night Retinol
Radical Night Retinol

Formulated with 1% retinol to improve

skin texture + uneven pigmentation

$200.00
4.4 (361)
Firming Serum Firming Serum
Best Seller
Firming Serum

Lightweight serum that supports visible improvement

of firmness + sagging

$265.00
4.3 (394)
Daily Power Defense Daily Power Defense
Best Seller
Daily Power Defense

Advanced barrier serum that defends against

environmental stressors + premature signs of aging

$190.00
Size
50 mL / 1.7 Fl. Oz.
4.5 (754)
Illuminating AOX Serum Illuminating AOX Serum
New Beauty
Illuminating AOX Serum

Concentrated antioxidant serum that

defends against pollution + premature signs of aging

$195.00
4.0 (143)
Enzymatic Peel Enzymatic Peel
Enzymatic Peel

Rejuvenating at-home peel that soothes + hydrates skin

$92.00
4.4 (221)
Recovery Crème Recovery Crème
Recovery Crème

Luxuriously rich hydrator clinically proven to

rejuvenate the appearance of fragile skin and neck aging

$135.00
4.3 (271)
10 Percent Vitamin C Self-Activating 10 Percent Vitamin C Self-Activating
10% Vitamin C Self-Activating

Vitamin C brightens skin + promotes a more even skin tone

$112.00
Size
50 mL / 1.7 Fl. Oz.
4.3 (675)
Exfoliation Accelerator Exfoliation Accelerator
Exfoliation Accelerator

Glycolic and lactic acid complex designed to

exfoliate + brighten skin

$92.00
Size
50 mL / 1.7 Fl. Oz.
4.4 (198)
Instant Pore Refiner Instant Pore Refiner
Instant Pore Refiner

Lightweight serum that reduces surface oils

for an instantly matte finish

$68.00
4.0 (168)
Skin Brightening Evening + Brightening High Potency Retinol Program Skin Brightening Evening + Brightening High Potency Retinol Program
Skin Brightening Evening + Brightening High Potency Retinol Program

Comprehensive program designed to promote

a smooth, even skin tone

$290.00
3.9 (54)
Wrinkle + Texture 0.5% Wrinkle + Texture 0.5%
Wrinkle + Texture

Formulated with 0.5% retinol to support the

visible improvement of wrinkles & skin texture

$175.00
Size
50 mL / 1.7 Fl. Oz.
4.4 (9)

You've viewed 21 of 21 products

Shop by concern

Frequently Asked Questions

How do I build an anti-aging skincare routine?

Start with Getting Skin Ready®: cleanse, exfoliate, tone. Then apply Prevent + Correct products AM and PM. Finish every morning with ZO® sunscreen. Your physician customizes the specific products and concentrations for your skin.

Should I use anti-aging cream in the morning or at night?

Most ZO® anti-aging formulas suit AM and PM use. Radical Night Retinol is specifically formulated for PM. Every morning system ends with a ZO sunscreen delivering Triple-Spectrum Protection®. Your physician determines your complete protocol.

What is the best skincare ingredient for anti-aging?

ZO® formulas combine retinoids, ZCORE®, ZPRO®, Vitamin C, Vitamin E, niacinamide, and alpha hydroxy acids, each targeting specific aging concerns. Your physician identifies the right combination for your skin.

Does anti-aging skincare work?

Yes, but formulation quality determines results. ZO® builds on clinically shown technologies including microencapsulated retinols, bioengineered plant stem cell complexes, and proprietary delivery systems, all developed by Zein Obagi MD over 35+ years.

When should I start using anti-aging creams?

There is no fixed starting age: it depends on your skin concerns and goals. Prevention can start in your mid-twenties. Consult a ZO provider to determine the right time and approach for you.

Why use anti-aging skincare products from ZO Skin Health?

ZO is physician-founded with nearly two decades of clinical innovation. Products are clinically shown and award-recognized by Cosmopolitan, Elle, and Harper's Bazaar, dispensed through a global network of authorized physicians.