ZO Skin Health is one of a select few professional skin care lines with a broad range of medical grade skincare comprising advanced skincare protocols and products that prevent aging and offer exceptional skin protection from environmental damage. ZO’s therapeutic treatment protocols and highly effective targeted skin care solutions help reinforce and maintain optimal skin health. Based on the latest scientific advances in skin therapy technologies, our products and protocols help physicians provide continuous skin health care for all skin types, genders and ages.

Skincare Product Innovation

At ZO Skin Health, we believe that the only way to achieve optimal skin health is through the power of science. Founded by world-renowned dermatologist Dr. Zein Obagi, we push the boundaries of medical grade skincare by providing the most innovative skincare products powered by cutting-edge formulas and technologies. Our products and protocols are clinically recognized for their exceptional efficacy as some of the best skin care for aging skin – suitable for maintaining skin health for anyone, regardless of age, ethnicity, unique skin condition or skin type.
Bottle of Firming Serum with product in petri dish


ZO Skin Health’s technological expertise sets us apart. Our proprietary technologies are core to the development of formulations that achieve superior outcomes. ZO technologies are multi-modal, allowing for the most comprehensive approach to skin health, and are always paired with a delivery system that enables greater penetration and precision. From skin firming ZCORE™ to complete skin protection with Triple- Spectrum Protection and our award-winning retinol skin brightener formulations, our products and protocols address the most serious skin concerns at every stage of life.
ZCORE - Targeted firming complex. Improves the visible appearance of skin sagging, including neck skin ZPRO - Biomimetic sericin protein complex. Minimizes the look of fine lines while enhancing skin plumpness + hydration from within. ZO-RRS2 - Redness-reducing plant stem cell complex. Helps to powerfully neutralize aging free radicals while soothing visible redness. ZOX 12 - 12-hour antioxidant complex. Encapsulated vitamins A, C and E slow-release in skin to deliver 12 hours of free radical protection. ZPOLY - Plant derived polysaccharide complex. Minimizes signs of premature aging while infusing extended hydration + strengthening skin's barrier.
ZO Skin Health’s extensive clinical studies demonstrate the exceptional efficacy of the ZO Skin Health portfolio of products and protocols. Capturing real results from real patients, our scientific analyses demonstrate our ongoing commitment to the ZO philosophy that skin health can and should be supported by science.
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  • Firming Serum is clinically proven to visibly improve skin’s elasticity.
  • 88% elasticity improvement was measured at 12 weeks.


  • Firming Serum is clinically proven to improve the appearance of firmness.
  • 97% of participants showed significant improvement in skin firmness by week 12.


  • Firming Serum is clinically proven to improve the appearance of sagging skin.
  • 93% of participants showed significant improvement in both mid-face and jawline skin sagging by week 12.


  • 89% of patients showed significant improvement in skin hydration by week 4.


  • 70% of patients showed significant improvement in redness by week 8.

Texture + Smoothness

  • 100% of patients showed significant improvement in texture and smoothness by week 8. 


  • 82% of patients reported diminished itching by week 8.


  • Wrinkle + Texture Repair is clinically proven to improve skin function and the skin’s ability to retain hydration.
  • 95% of participants showed improvement in skin function by week 12.


  • Wrinkle + Texture Repair is clinically proven to improve the appearance of lines and wrinkles.
  • 98% of participants showed improvement in crow’s feet and facial fine lines by week 12.


  • Wrinkle + Texture Repair is clinically proven to improve the appearance of smooth texture.
  • 93% of participants showed improvement in skin texture by week 12.


Research + Development

ZO Skin Health’s Research and Development team focuses on finding unique ingredients that work synergistically to deliver innovative products that our physicians and patients expect from a medical grade skincare brand. Through a combination of professional collaborations, higher education partnerships and unrivaled technical expertise, our R&D team continues to deliver exceptional industry-leading products and protocols for patent-worthy results.