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Peptide Facial Refining Concentrate

$265.00
30 mL / 1 Fl. Oz.

Peptide Facial Refining Concentrate is a high-potency product. It is only available for purchase via our network of clinical professionals.

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Visibly lifted, sculpted, more defined in 12 weeks. This concentrated peptide serum visibly smooths expression lines and restores the look of lost volume, visibly lifting and re-sculpting facial contours for more youthful definition. Use on its own or to complement injectable treatments.


Clinically tested | Free of Paraben, SLS, SLES, Phthalates, and Gluten

All skin types
Lift and definition
Volume and smoothness
Lines and wrinkles
Pairing with injectables

Acetyl Octapeptide-3: Targets the appearance of dynamic lines + wrinkles, especially around the forehead + eye area, helping this anti-wrinkle peptide serum deliver visibly smoother skin
Acetyl Hexapeptide-8: Provides greater precision in smoothing the appearance of deeper dynamic + static wrinkles
Refining Peptide Complex: A key component of this sculpting peptide serum, supporting a more visibly refined facial geometry
Volumizing Tripeptide: Supports hyaluronic acid production for fuller, plumper-looking skin
ZPOLY™ Complex: Soothes visible redness + reinforces the skin barrier, helping maintain comfort and resilience while optimizing results from this high-performance anti-wrinkle serum

Mentioned in Best of the Beauty Closet: 20 New Products We Tried and Loved in March - Cosmopolitan

For Better Results, Pair With:

CLINICALLY SHOWN RESULTS

Smoother, Fuller, More Sculpted in 12 Weeks*

92%

saw a reduction in the appearance of fine lines

82%

saw a reduction in visible forehead wrinkles

96%

said their skin was smoother looking

84%

said they had a visibly younger-looking facial geometry

86%

saw a visible improvement in facial hollow areas

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Science and Ingredients

Collagen Changes Structure Over Time

In young skin, collagen forms a web that keeps the face firm and defined. With age, it realigns into stiff bundles, and skin loses that structure. This four-peptide blend helps refine it, for visibly lifted, more sculpted looking contours.

Enhance Visible Skin Volume and Hydration

This potent neuropeptide helps modulate wrinkles for visibly smoother expression lines, while supporting skin's natural hyaluronic acid production to boost hydration and enhance facial volume for more refined-looking skin.

Smooth and Prevent Expression Lines

Working in synergy with Acetyl Octapeptide-3, this amplified neuropeptide helps smooth the appearance of deeper dynamic and static wrinkles while helping to support skin's natural collagen for a smoother-looking complexion.

Designed to Visibly Modulate Wrinkles

A blend of two active peptides works to support skin's optimal structural integrity, resulting in a visible lifted effect for a more refined and sculpted looking facial geometry. This powerful complex supports the appearance of skin firmness and suppleness.

Less Redness. More Resilience.

A complex that combines four polysaccharide extracts to reduce visible redness and provide skin barrier support.

Maximize Your Skin Health Investments

Peptide Facial Refining Concentrate is a perfect pairing for injectable procedures and dermal fillers. Designed to enhance skin's volume and firmness for visibly fuller-looking skin that complements your skin health investments.

EXPERT GUIDANCE

Use AM + PM after Getting Skin Ready® (cleanse, exfoliate, tone).

Apply to clean, dry skin. Spread Peptide Facial Refining Concentrate evenly over the face, using upward and outward motions until absorbed.

Apply after Getting Skin Ready® as the Correct step of your ZO® system. Follow with SPF in the morning.

Results are cumulative and build with consistent daily use. In clinical studies, users saw improvements in appearance of fine lines/wrinkles and younger-looking facial geometry

Expert Guidance

TRUSTED BY PROFESSIONALS

"I used to require around 50 units of neurotoxin every 3 months. I have been using the Peptide Facial Refining Concentrate, 2 pumps morning & night for three months now and not only have I not needed neurotoxin for 4.5 months but when I went to get it the other day, I only needed 25 units for the same treatment. My skin is looking better than ever."
Dr. Jared Garlick Garlick Plastic Surgery (patient quote)
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Customer Reviews

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Frequently Asked Questions

What does Peptide Facial Refining Concentrate do?

ZO® Peptide Facial Refining Concentrate is an advanced wrinkle-modulating and plumping serum that reduces the appearance of static and dynamic lines and wrinkles, supports skin's natural hyaluronic acid production to visibly plump skin and improve hollow areas, and results in a more balanced-looking, naturally sculpted facial geometry.

What ingredients are in Peptide Facial Refining Concentrate?

ZO® Peptide Facial Refining Concentrate is powered by four peptide technologies. Acetyl Octapeptide-3 helps modulate muscle stimulation signals to reduce the visible impact of dynamic expression lines. Acetyl Hexapeptide-8 inhibits neurotransmitter activity to reduce the strength of muscle contraction, visibly relaxing tissue and smoothing lines. The Refining Peptide Complex stimulates DEJ protein expression and supports collagen fiber organisation for improved facial geometry and structural integrity. The Volumizing Tripeptide supports the skin's natural hyaluronic acid production for enhanced volume and fuller-looking skin. ZPOLY™ reduces the effects of inflammasome-triggered enzymes and creates an optimally hydrated environment that supports the efficacy of the other actives in the formula.

How do I use Peptide Facial Refining Concentrate?

After Getting Skin Ready® (cleanse, exfoliate, tone), apply ZO® Peptide Facial Refining Concentrate to clean, dry skin AM and PM. Use with other ZO® Prevent + Correct products as directed by your physician. Follow with SPF in the morning.

Can Peptide Facial Refining Concentrate be used with neurotoxins or dermal fillers?

Yes. ZO® Peptide Facial Refining Concentrate is designed to complement the visible effects of neurotoxins and dermal fillers, and can also be used as a standalone anti-aging serum for those not pursuing injectable treatments. Your physician can advise on how to integrate it into your ZO® system alongside or in place of injectable procedures.

What results can I expect from Peptide Facial Refining Concentrate?

ZO® Peptide Facial Refining Concentrate is backed by a 12-week independent, third-party clinical study of 49 subjects (females aged 47-72, Fitzpatrick skin types I-VI), supported with use of Gentle Cleanser and Sheer Fluid Broad-Spectrum Sunscreen SPF 50. Results: 92% saw a reduction in the appearance of fine lines; 82% saw a reduction in visible forehead wrinkles; 96% said their skin looked smoother; 84% said they had a visibly more balanced-looking facial geometry; and 86% saw a visible improvement in facial hollow areas. Individual results vary based on skin condition, age, and consistency of use.

Is Peptide Facial Refining Concentrate fragrance-free?

Yes. ZO® Peptide Facial Refining Concentrate is alcohol- and fragrance-free.