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Growth Factor Serum

$200.00
30 mL / 1 Fl. Oz.

Growth Factor Serum is a high-potency product. It is only available for purchase via our network of clinical professionals.

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Skin looks 6 years younger in 8 weeks. This advanced serum is clinically shown to improve the appearance of skin density, elasticity, firmness, and smoothness. Formulated with safely synthetsized growth factors, it supports the skin's natural repair process and strengthens skin's structural foundation.


Clinically tested | Free of Paraben, SLS, SLES, Phthalates, and Gluten

All skin types
Skin density and elasticity
Wrinkles and fine lines
Smoothness and suppleness
Radiance and texture

Human-comparable Growth Factor Technology: Works to reverse the visible signs of aging and aid in the appearance of skin rejuvenation and vitality.
Plant- + Enzymatically-Derived Growth Factors: Restores the appearance of skin density, compactness, and visible strength.
Dipeptide diaminobutyroyl benzylamide diacetate: Minimizes the appearance of expression lines
ZPRO®: Supports skin’s natural replenishment of hyaluronic acid

2026 Best Growth Factor, The Shape Skin Awards: Editor-Tested & Dermatologist Approved Breakthrough, Shape

2026 Best Growth Factor Serum, The Midlife Beauty O-wards, Oprah Daily

2025 Best Face Serum, Grooming Awards: Face Care Products, AskMen

2023 Best Anti-Aging Serum with Growth Factor, Cosmo Love, Cosmopolitan

For Better Results, Pair With:

CLINICALLY SHOWN RESULTS

Skin Looks 6 Years Younger in 8 Weeks*

100%

agreed their skin looked lifted and supported*

98%

agreed their skin felt thicker, more cushioned, and more structurally intact**

98%

agreed their skin looked rejuvenated***

42%

improvement in visible radiance & texture*

26%

improvement in hydration**

16%

improvement in elasticity**

15%

improvement in appearance of fine lines*

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Science and Ingredients

Healthy Skin Knows How to Repair Itself. With Age, It Just Needs Reminding.

Growth Factor Serum is designed to support the skin's natural renewal processes and key components associated with firmness and youthful apperance.

Hydration Isn't Lost. It Just Needs Replenishing.

ZPRO(R) is a protein complex that supports skin's natural replenishment of hyaluronic acid for a more supple and hydrated appearance. It minimizes the look of fine lines while hydrating from within.

Regenerative Skincare That's Stable and Effective.

Unlike human-derived growth factors, our Human-Comparable Growth Factor (HCGF) technology uses sustainable, plant- and enzymatically-derived ingredients to ensure stable product potency. This complex features targeted growth factors to support the skin's foundational components, the integrity of the natural extracellular matrix, as well as the appearance of skin vitality through optimal nutrient delivery.

Skin Vitality Starts with the Right Signals.

Dipeptide Diaminobutyroyl Benzylamide Diacetate (DDBD) is a peptide that signals skin cells to temporarily reduce the appearance of expression lines, for a smoother and more refreshed appearance.

EXPERT GUIDANCE

Apply AM + PM on clean, dry skin. Growth factors work gradually over weeks. Use consistently for best results.

Apply 1-2 pumps to face, neck, and eye areas.

Start with the Getting Skin Ready® system to cleanse, exfoliate, and tone. Follow with Daily Power Defense. Apply Growth Factor Serum last in your regimen. Follow with SPF in the morning.

Results are gradual with consistent use. In clinical studies, users saw softer, more hydrated skin after just 2 weeks. After 8 weeks of twice-daily use, visible improvements in thicker, smoother, more supple skin were reported, with continued improvement through 12 weeks.

Since Growth Factor Serum supports skin restoration and renewal, concurrent use with broad-spectrum sun protection is essential to protect newly regenerated skin from UV damage and maintain clinical benefits

Expert Guidance

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Frequently Asked Questions

What is a growth factor serum?

A growth factor serum is a skincare product formulated with signaling proteins that communicate with skin cells to encourage natural regeneration, help improve the appearance of skin density and elasticity, and support long-term skin health. ZO Growth Factor Serum uses safely synthesised, human-comparable growth factors for maximum skin compatibility.

How do I use growth factor serum?

Start with your Getting Skin Ready® system: cleanse, exfoliate, and tone. Then move into Step 2 of your ZO® protocol. Apply Daily Power Defense first, followed by any other Prevent + Correct products recommended by your physician, and finish with Growth Factor Serum last. In the morning, complete your system with a broad-spectrum SPF 40 or higher sunscreen. Use twice daily as directed by your ZO® protocol.

Is growth factor serum safe to use during pregnancy?

We recommend consulting your physician or an authorised ZO provider before using any active skincare formulation during pregnancy or while breastfeeding.

Can I use growth factor serum with retinol?

Yes. Growth Factor Serum is formulated to work within the ZO protocol alongside retinol-based products. Apply Growth Factor Serum first on clean, dry skin, allow it to absorb fully, then layer your retinol product as directed by your ZO® protocol.

How soon will I see results from growth factor serum?

In ZO's independent third-party clinical study, users reported visible improvement: thicker, smoother, more supple skin that appears nearly 6 years younger, after just 8 weeks of twice-daily use, with continued improvement through 12 weeks.

What makes ZO Growth Factor Serum different from other growth factor serums?

Growth Factor Serum is differentiated on three dimensions. It uses human-comparable Sh-Oligopeptide growth factors rather than plant-only alternatives, offering superior skin compatibility. Its proprietary ZPRO® complex supports the skin's own hyaluronic acid and collagen production. And its efficacy is backed by a 12-week independent third-party clinical study of 46 subjects, not internal testing.