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Daily Power Defense

$190.00
Size
50 mL / 1.7 Fl. Oz.

Daily Power Defense is a high-potency product. It is only available for purchase via our network of clinical professionals.

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Visibly healthier skin in just 2 weeks. Our best-selling antioxidant serum strengthens skin's protective barrier and defends against the environmental stressors that speed up aging, so skin stays hydrated, calm, and resilient. The daily-defense foundation of healthy, youthful skin.


Clinically tested | Free of Paraben, SLS, SLES, Phthalates, and Gluten

All skin types
Barrier strength and hydration
Radiance and even tone
Premature aging

Vitamins A + E: Potent antioxidants that protect against environmental skin aging
ZO-RRS2®: Exclusive plant stem cell complex that helps to neutralize free radicals while soothing visible redness
ZPOLY™: Exclusive plant-derived polysaccharide complex that minimizes signs of premature aging while infusing extended hydration
Micrococcus lysate, arabidopsis thaliana extract: Specialized enzymes that encourage optimum skin cell health

2026 The Winter Skincare Basics (Mention), InsideHook

For Better Results, Pair With:

CLINICALLY SHOWN RESULTS

Achieve Healthier, Hydrated, Even Looking Skin

92%

of participants said skin appears healthier by week 2

92%

of participants said skin maintains visual uniformity throughout the day by week 4

84%

of participants said skin feels soothed and it stays hydrated throughout the day

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Science and Ingredients

Even Healthy Skin Needs A Defense System

Over time, skin loses its ability to withstand daily external and internal stressors, like pollution and free radicals. Unlike acute inflammation, chronic inflammation begins to exhaust skin's ability to defend and regenerate, resulting in damage known as "inflammaging."

Set Lasting Results in Motion

ZPOLY™ is a complex of 4 polysaccharide extracts that help prevent the appearance of premature aging. This multi-action antioxidant supports skin barrier restoration to protect against future stressors, boosts extended hydration after a single application, and minimizes redness.

Antioxidant Protection

Vitamins A + E serve as powerful antioxidants helping to protect your skin. These potent ingredients are essential in defending skin against environmental aging.

Defend and Soothe

An exclusive plant stem cell complex provides the first line of defense by neutralizing free radicals, while calming visible redness.

EXPERT GUIDANCE

Use daily as part of your morning and evening routines.

Apply 1-2 pumps to face, neck, and décolletage.

Use after cleansing, exfoliating, and toning skin. Always follow with SPF in the morning. If layering with Growth Factor Serum, apply Daily Power Defense first.

Skin feels more hydrated in as little as 8 hours. By week 2, skin tone looks more even and radiant. By week 4, skin appears calmer, with less visible blotchiness. By week 8, the appearance of crow's feet is visibly reduced, with continued improvement in skin's overall look. For best results, use daily as part of your ZO® regimen.

Expert Guidance

Customer Reviews

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Build a Balanced Regimen

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Frequently Asked Questions

Does ZO Daily Power Defense contain retinol?

No. ZO® Daily Power Defense does not contain retinol. It is formulated as an environmental defense and antioxidant serum rather than a retinol treatment. If you are looking for a dedicated retinol product, your physician can recommend the appropriate option within the ZO® system.

What does ZO Daily Power Defense do?

ZO® Daily Power Defense is an advanced antioxidant serum formulated to defend skin against the cumulative effects of daily environmental stress. It neutralizes free radicals, visibly reduces signs of inflammation, accelerates barrier restoration and extended hydration, and supports the skin's natural cellular repair processes. ZO® Daily Power Defense is designed to serve as a foundational daily serum for all skin types, used AM and PM as part of the Prevent step of your ZO® system, after Getting Skin Ready® and before SPF in the morning.

Is ZO Daily Power Defense a moisturizer or a serum?

ZO® Daily Power Defense is a multi-action antioxidant serum. While it contains ingredients that support skin hydration and barrier restoration, it is formulated primarily as an environmental defense serum. It can be layered under a dedicated hydrator in the AM or used as part of your PM Prevent step within your ZO® system.

How do I use ZO Daily Power Defense in my routine?

Daily Power Defense is applied as part of the Prevent step of your ZO® system, after Getting Skin Ready® (cleanse, exfoliate, tone). In the AM, apply 1–2 pumps to face, neck, and décolletage after toning, then follow with SPF. In the PM, apply after toning as part of your active treatment step. Daily Power Defense can be used morning and evening. If layering with Growth Factor Serum, apply Daily Power Defense first.

Can I use ZO Daily Power Defense at night?

Yes. ZO® Daily Power Defense is formulated for both AM and PM use. At night, apply after Getting Skin Ready® (cleanse, exfoliate, tone) as part of your Prevent step, before any moisturizer. Your physician can advise on optimal layering order based on the other active products in your ZO® system.