A derivative of vitamin A, ReFissa’s® new formulation of tretinoin reduces fine lines and tactile roughness of the skin and helps delete irregular pigmentation from the sun.
It is the only US Food and Drug Administration (FDA) approved prescription cream with a .05% strength emollient base designed to reduce fine facial wrinkles, correct irregular pigmentation, and smooth substantial skin roughness. ZO Skin Health, Inc. now owns ReFissa® as well as its generic equivalent tretinoin.
So how effective is ReFissa? 71% of women saw improvement in their fine facial wrinkles, and 83% saw improvement in hyperpigmentation in a company-sponsored study. Moreover, continued improvement occurred over the 6-month study period. Side effects may initially occur, which include: flaking, irritation or redness. Dr. Zein Obagi suggests using the product every other night until the skin adjusts, which typically occurs within a month. Gently wash face using a mild soap or cleanser, pat dry and wait 20 to 30 minutes before applying ReFissa as this can reduce the chance of skin irritation, he notes.
A pearl-sized amount of is enough to cover your cheeks, forehead and chin. Spread evenly on the face, avoiding eyes and the skin around nose, ears and lips.
Refissa works in tandem with the ZO® Melamix® skin lightener to help blend the skin to create a more even skin tone.
Using sunscreen such as Oclipse® Smart Tone SPF 50 is important as retinoids like Refissa can increase sun sensitivity. To locate a ZO skincare specialist near you, visit https://zoskinhealth.com/zo-near-you.